2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Ser/Thr Protease

Ser/Thr Protease

Serine proteases; Serine endopeptidases; Threonine proteases

Ser/Thr Protease

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Serine (Ser) proteases catalyse the hydrolysis of specific peptide bonds in their substrates and this activity depends on a set of amino acids in the active site of the enzyme, one of which is always a serine. There are two families especially well studied, the trypsin family and the subtilisin family. Serine proteases play crucial roles in a wide variety of cellular as well as extracellular functions, including the process of blood clotting, protein digestion, cell signaling, inflammation, and protein processing. Threonine (Thr) proteases are a family of proteolytic enzymes harbouring a threonine residue within the active site. The prototype members of this class of enzymes are the catalytic subunits of the proteasome, however the acyltransferases convergently evolved the same active site geometry and mechanism.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-129027
    Ac-Leu-Gly-Lys(Ac)MCA
    Ac-Leu-Gly-Lys(Ac)MCA is a Trypsin fluorescence substrate.
    Ac-Leu-Gly-Lys(Ac)MCA
  • HY-169817
    PAR-2-IN-2
    		Inhibitor
    PAR-2-IN-2 (compound P-596) is a protease-activated receptor 2 (PAR-2) inhibitor with an IC50 of 10.79 μM for SLIGKV and an IC50 of greater than 200 μM for Trypsin.
    PAR-2-IN-2
  • HY-P990524
    Anti-TMPRSS2 Antibody
    		Inhibitor
    The Anti-TMPRSS2 Antibody is a CHO-expressed humanized antibody that targets TMPRSS2. The Anti-TMPRSS2 Antibody features a huIgG1 heavy chain and a huκ light chain, with an expected molecular weight (MW) of 150 kDa. For the isotype control of the Anti-TMPRSS2 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-TMPRSS2 Antibody
  • HY-D0837R
    Imidazole (Standard)
    		Inhibitor
    Imidazole (Standard) is the analytical standard of Imidazole. This product is intended for research and analytical applications. Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CLPro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease.
    Imidazole (Standard)
  • HY-B1624
    Debrisoquin
    		Inhibitor
    Debrisoquin (Isocaramidine) is a TMPRSS2 inhibitors that inhibits SARS-CoV-2 entry into human lung cell line by a TMPRSS2-depedent manner, with an IC50 of 22μM. Debrisoquin can be used for antiviral research.
    Debrisoquin
  • HY-P2033
    Nostopeptin B
    		Inhibitor
    Nostopeptin B is a cyclic dipeptide that can be isolated from N. minutum (NIES-26). The structure of Nostopeptin B contains Ahp (3-amino-6-hydroxy-2-piperidone), which exhibits effective inhibition against elastase and chymotrypsin.
    Nostopeptin B
  • HY-106448
    Midesteine
    		Inhibitor
    Midesteine (MR 889) is a proteinase inhibitor that can inhibit porcine pancreatic elastase, human neutrophil elastase and bovine chymotrypsin. Midesteine has the potential for chronic obstructive pulmonary disease (COPD) and chronic bronchitis research.
    Midesteine
  • HY-N13957
    Bacithrocin C
    		Inhibitor
    Bacithrocin C is a thrombin inhibitor that inhibits thrombin, factor Xa, trypsin and Papain with IC50s of 80 μM, 15 μM, 1.3 μM, and 0.02 μM, respectively.
    Bacithrocin C
  • HY-113844
    Ac-Gly-Lys-OMe
    Ac-Gly-Lys-OMe is a substrate for urokinase. Ac-Gly-Lys-OMe can be used to measure the effects of small molecule inhibitors on urokinase activity.
    Ac-Gly-Lys-OMe
  • HY-118177
    Neutrophil elastase inhibitor 1
    		Inhibitor
    Neutrophil elastase inhibitor 1 (Compound 5b) is a competitive, pseudoirreversible inhibitor for neutrophil elastase with an IC50 of 7 nM.
    Neutrophil elastase inhibitor 1
  • HY-149680
    CatD-P1
    CatD-P1is a pH insensitive CatD (Cathepsin D) probe.
    CatD-P1
  • HY-172207
    POPTc80-IN-1
    		Inhibitor
    POPTc80-IN-1 (Compound LC-45) is a competitive inhibitor for prolyl oligopeptidase of Trypanosoma cruzi POPTc80 with an IC50 of 0.23 μM and a Ki of 0.054 μM. POPTc80-IN-1 inhibits the invasion of T. cruzi into host cell with an IC50 of 46.71 μM.
    POPTc80-IN-1
  • HY-119337
    CE-2072
    		Inhibitor
    CE-2072 is an inhibitor of serine proteases neutrophil elastase and proteinase-3. CE-2072 inhibits HIV-1 production and p24 production in response to IL-18 or NaCl in infected U1 monocytic cells, reduces virus replication in infected peripheral blood mononuclear cells and blocks infection of permissive HeLa cells. CE-2072 suppresses activation of the HIV-1-inducing transcription factor NF-kB in U1 cells. CE-2072 is promising for research of HIV-1-related disease.
    CE-2072
  • HY-N13955
    Bacithrocin B
    		Inhibitor
    Bacithrocin B is a thrombin inhibitor that inhibits thrombin, factor Xa, trypsin and Papain with IC50s of 84 μM, 17 μM, 1.7 μM, and 0.02 μM, respectively.
    Bacithrocin B
  • HY-W415273
    Caspase-3-IN-2
    		Inhibitor
    Caspase-3-IN-2 (Compound 4d) is the inhibitor for α-Chymotrypsin. Caspase-3-IN-2 also exhibits inhibitory activity against HIV protease and caspase 3 with an inhibition rate of 57% and 51% at 100 μM.
    Caspase-3-IN-2
  • HY-N14772
    Laccaridione A
    		Inhibitor
    Laccaridione A can inhibit the activity of antiserine protease. Laccaridione A inhibits trypsin, papain, thermophilic protease, collagenase and zinc protease with IC50s of 14.7 μg/mL, 2.5 μg/mL, 18.8 μg/mL, 7.2 μg/mL and 18.2 μg/mL, respectively.
    Laccaridione A
  • HY-114080R
    Patamostat (Standard)
    		Inhibitor
    Patamostat (Standard) is the analytical standard of Patamostat. This product is intended for research and analytical applications. Patamostat (E-3123) is a potent protease inhibitor. Patamostat potently inhibits trypsin, plasmin and thrombin with IC50s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat may possess suppressing effects on pathogenesis and development of acute pancreatitis.
    Patamostat (Standard)
  • HY-N14773
    Laccaridione B
    		Inhibitor
    Laccaridione B can inhibit the activity of antiserine protease. Laccaridione B inhibits trypsin, papain, thermophilic protease, collagenase and zinc protease with IC50s of 10.9 μg/mL, 5.1 μg/mL, 8.4 μg/mL, 5.7 μg/mL and 3.0 μg/mL, respectively. Laccaridione B also has a strong anti-proliferative activity against L-929, K-562 and HeLa cells with IC50s of 2.4 μg/mL, 1.8 μg/mL and 13.9 μg/mL, respectively.
    Laccaridione B
Cat. No. Product Name / Synonyms Application Reactivity