2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Ser/Thr Protease

Ser/Thr Protease

Serine proteases; Serine endopeptidases; Threonine proteases

Ser/Thr Protease

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Serine (Ser) proteases catalyse the hydrolysis of specific peptide bonds in their substrates and this activity depends on a set of amino acids in the active site of the enzyme, one of which is always a serine. There are two families especially well studied, the trypsin family and the subtilisin family. Serine proteases play crucial roles in a wide variety of cellular as well as extracellular functions, including the process of blood clotting, protein digestion, cell signaling, inflammation, and protein processing. Threonine (Thr) proteases are a family of proteolytic enzymes harbouring a threonine residue within the active site. The prototype members of this class of enzymes are the catalytic subunits of the proteasome, however the acyltransferases convergently evolved the same active site geometry and mechanism.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W018781R
    Benzamidine hydrochloride (Standard)
    		Inhibitor
    Benzamidine hydrochloride is a trypsin-like serine proteases with Kis of 20, 21, 97, 110, 320 and 750 μM against Tryptase, Trypsin, uPA, Factor Xa, Thrombin and tPA, respectively.
    Benzamidine hydrochloride (Standard)
  • HY-N13950
    Bacithrocin A
    		Inhibitor
    Bacithrocin A is a thrombin inhibitor that inhibits thrombin, factor Xa, trypsin and Papain with IC50s of 48 μM, 13 μM, 0.65 μM, and 0.02 μM, respectively.
    Bacithrocin A
  • HY-P990617
    Anti-Hepcidin/HAMP Antibody (LY2787106)
    		Inhibitor
    Anti-Hepcidin/HAMP Antibody (LY2787106) is a CHO-expressed human antibody that targets Hepcidin/HAMP.Anti-Hepcidin/HAMP Antibody (LY2787106) has a huIgG4SP type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 144.2 kDa. The isotype control for Anti-Hepcidin/HAMP Antibody (LY2787106) can be referred to as Human IgG4 kappa, Isotype Control (HY-P99003).
    Anti-Hepcidin/HAMP Antibody (LY2787106)
  • HY-33900R
    Dihydrofuran-3(2H)-one (Standard)
    		Inhibitor
    Dihydrofuran-3(2H)-one (Standard) is the analytical standard of Dihydrofuran-3(2H)-one. This product is intended for research and analytical applications. Dihydrofuran-3(2H)-one (3-Oxotetrahydrofuran) is a cyclic ketone that can be used to synthesize cyclic ketone inhibitors that inhibit the serine protease plasmin.
    Dihydrofuran-3(2H)-one (Standard)
  • HY-109127R
    Berotralstat (Standard)
    		Inhibitor
    Berotralstat (Standard) is the analytical standard of Berotralstat. This product is intended for research and analytical applications. Berotralstat (BCX7353) is an orally active plasma kallikrein inhibitor. Berotralstat can reduce brain edema and is being studied for glioblastoma and hereditary angioedema.
    Berotralstat (Standard)
  • HY-159847
    Nacresertib
    		Inhibitor
    Nacresertib is a Ser/Thr Protease inhibitor.
    Nacresertib
  • HY-E70230
    Staphylokinase, staphylococcus aureus
    		Activator
    Staphylokinase, staphylococcus aureus (SAK) is a fibrin-specific plasminogen activator. Staphylokinase is an efficient, fibrin-selective thrombolytic agent.
    Staphylokinase, staphylococcus aureus
  • HY-B0190AR
    Nafamostat mesylate (Standard)
    		Inhibitor
    Nafamostat (mesylate) (Standard) is the analytical standard of Nafamostat (mesylate). This product is intended for research and analytical applications. Nafamostat mesylate (FUT-175), an anticoagulant, is a synthetic serine protease inhibitor. Nafamostat mesylate has anticancer and antivirus effect. Nafamostat mesylate induce apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1). Nafamostat mesylate can be used in the development of the pathological thickening of the arterial wall.
    Nafamostat mesylate (Standard)
  • HY-129027
    Ac-Leu-Gly-Lys(Ac)MCA
    Ac-Leu-Gly-Lys(Ac)MCA is a Trypsin fluorescence substrate.
    Ac-Leu-Gly-Lys(Ac)MCA
  • HY-169817
    PAR-2-IN-2
    		Inhibitor
    PAR-2-IN-2 (compound P-596) is a protease-activated receptor 2 (PAR-2) inhibitor with an IC50 of 10.79 μM for SLIGKV and an IC50 of greater than 200 μM for Trypsin.
    PAR-2-IN-2
  • HY-P990524
    Anti-TMPRSS2 Antibody
    		Inhibitor ≥99.0%
    The Anti-TMPRSS2 Antibody is a CHO-expressed humanized antibody that targets TMPRSS2. The Anti-TMPRSS2 Antibody features a huIgG1 heavy chain and a huκ light chain, with an expected molecular weight (MW) of 150 kDa. For the isotype control of the Anti-TMPRSS2 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-TMPRSS2 Antibody
  • HY-D0837R
    Imidazole (Standard)
    		Inhibitor
    Imidazole (Standard) is the analytical standard of Imidazole. This product is intended for research and analytical applications. Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CLPro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease.
    Imidazole (Standard)
  • HY-B1624
    Debrisoquin
    		Inhibitor
    Debrisoquin (Isocaramidine) is a TMPRSS2 inhibitors that inhibits SARS-CoV-2 entry into human lung cell line by a TMPRSS2-depedent manner, with an IC50 of 22μM. Debrisoquin can be used for antiviral research.
    Debrisoquin
  • HY-P2033
    Nostopeptin B
    		Inhibitor
    Nostopeptin B is a cyclic dipeptide that can be isolated from N. minutum (NIES-26). The structure of Nostopeptin B contains Ahp (3-amino-6-hydroxy-2-piperidone), which exhibits effective inhibition against elastase and chymotrypsin.
    Nostopeptin B
  • HY-106448
    Midesteine
    		Inhibitor
    Midesteine (MR 889) is a proteinase inhibitor that can inhibit porcine pancreatic elastase, human neutrophil elastase and bovine chymotrypsin. Midesteine has the potential for chronic obstructive pulmonary disease (COPD) and chronic bronchitis research.
    Midesteine
  • HY-N13957
    Bacithrocin C
    		Inhibitor
    Bacithrocin C is a thrombin inhibitor that inhibits thrombin, factor Xa, trypsin and Papain with IC50s of 80 μM, 15 μM, 1.3 μM, and 0.02 μM, respectively.
    Bacithrocin C
  • HY-113844
    Ac-Gly-Lys-OMe
    Ac-Gly-Lys-OMe is a substrate for urokinase. Ac-Gly-Lys-OMe can be used to measure the effects of small molecule inhibitors on urokinase activity.
    Ac-Gly-Lys-OMe
  • HY-118177
    Neutrophil elastase inhibitor 1
    		Inhibitor
    Neutrophil elastase inhibitor 1 (Compound 5b) is a competitive, pseudoirreversible inhibitor for neutrophil elastase with an IC50 of 7 nM.
    Neutrophil elastase inhibitor 1
  • HY-149680
    CatD-P1
    CatD-P1is a pH insensitive CatD (Cathepsin D) probe.
    CatD-P1
  • HY-172207
    POPTc80-IN-1
    		Inhibitor
    POPTc80-IN-1 (Compound LC-45) is a competitive inhibitor for prolyl oligopeptidase of Trypanosoma cruzi POPTc80 with an IC50 of 0.23 μM and a Ki of 0.054 μM. POPTc80-IN-1 inhibits the invasion of T. cruzi into host cell with an IC50 of 46.71 μM.
    POPTc80-IN-1
Cat. No. Product Name / Synonyms Application Reactivity